Quercetin is a bioflavonoid with high antitumor activity that acts on cancers such as osteosarcoma and colon cancer by rebuilding the tumor microenvironment and alleviates liver damage by regulating the EGFR pathway (Choi et al., 2010; Lan et al., 2017; Hu et al., 2017; Carrasco-Torres et al., 2017; Massi et al., 2017), Quercetin can exert anti-tumor activity by targeting HSP70/90, P13K, and NF-B and has been reported in the treatment of hepatocellular carcinoma (Fernández, Fondevila & Méndez, 2019; Wang et al., 2011). Here, EGFR is linked to osteosarcoma.