IGHE and cancer: In cancer, besides the debated roles of mast cells, 1 tumor-associated tissue eosinophilia (TATE) and macrophage (TAM) infiltration are considered characteristics of on-site inflammation .2–6 These infiltrates could however contribute to anti-tumor responses via antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis (ADCP) when stimulated by IgE.