In healthy volunteer, and patient groups with primary or metastatic CRC, IgG4-stimulated M2 macrophages manifested lower surface CD206, CD163, and CD14 expression and higher CCL-1, IL-10, and IL-6 production, in an isotype-specific manner (Figure 6), a profile strongly resembling the M2b‐phenotype [17] (Repository Figure 7), and consistent with that we previously reported in an allergy model .23 This evidence concerns the gene IL6 and allergic disease.