In addition, we observed a negative correlation between MGMT mRNA expression and MGMT promoter methylation (averaged over CpG sites 75–78) in 41 IDH-mutant GBM cases, and significantly lower expression of MGMT mRNA in cases with higher (≥30%) MGMT promoter methylation (Supplementary Figure S3). The gene discussed is MGMT; the disease is glioblastoma.