IDH1 and central nervous system neoplasm: On the basis of these findings, the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) update 5 suggests that IDH-mutant GBM should be denoted astrocytoma, IDH-mutant, grade 4, but notes that this change in this terminology may be viewed as controversial and will require further discussion in context of the next WHO classification11.