In the HBV-HCC and HCV-HCC subgroups, the levels of AFU, GPC3, and GGT-II were significantly higher in the LC group than in the CH group (Figure 1B–1D), suggesting that elevated levels of these three biomarkers may be associated with the progression of hepatitis to liver cirrhosis. Here, GPC3 is linked to laryngotracheoesophageal cleft.