CASP3 and neoplasm: Finally, immunohistochemical staining of tumor tissues revealed that compared with nobiletin or palbociclib single agent treatment, a combination of the two agents inhibited cell growth (decrease of Ki-67 and increase of p27) and induced apoptosis (increase of cleaved caspase-3) (nobiletin or palbociclib vs. nobiletin + palbociclib: *P < 0.05; **P < 0.01; ***P < 0.001; Figure 8E) significantly more.