MAP2K1 and non-small cell lung carcinoma: Of the 40 genes highly associated with NSCLC, at least 4 copies of every gene were detected, among them BRAF and MAP2K1 had a maximum of 74 CNVs in all 17 PDXs, compared with a minimum of 45 CNVs of MLH1. In addition, a maximum of 180 CNVs were identified in LC00592, compared with a minimum of 110 CNVs in LC-00666 and LC-00374 (Figure 5B).