Western blot analysis of our cohorts also showed a significantly positive correlation between BYSL and RIOK2 expressions in glioma tissues (n = 33, R = 0.608, P < 0.001) but not in nontumor brain tissues (n = 9, R = 0.377, P = 0.317) (Figure 6H). This evidence concerns the gene RIOK2 and central nervous system cancer.