Western blot analysis showed that BYSL protein levels were increased in grade II (n = 11, P = 0.068), grade III (n = 11, P < 0.001), and grade IV (n = 11, P = 0.001) glioma tissues compared to those in nontumor brain tissues (n = 9) (Figure 1E, 1F). Here, BYSL is linked to central nervous system cancer.