RIOK2 and central nervous system cancer: Furthermore, we found a significantly positive correlation between BYSL and RIOK2 gene expressions in LGG (R = 0.49, P = 1.3e-32), GBM (R = 0.30, P = 7.8e-05), and various grades of glioma tissues (R = 0.253, P = 2.7e-05) by analyzing public datasets (Figure 6F, 6G).