BYSL and central nervous system cancer: Using our cohorts, i.e., 25 glioma tissues (grade II, n = 9; grade III, n = 8; and grade IV, n = 8) and 8 nontumor brain tissues, qRT-PCR assays showed increased BYSL mRNA levels in grade II (P < 0.001), grade III (P = 0.028), and grade IV (P < 0.001) glioma tissues (Figure 1D).