To better understand the role of MEIOB in breast cancer, we then knocked down MEIOB by using siRNA in MDA-MB-231 cells (Supplementary Figure S2A and S2B) and found that depletion of MEIOB in MDA-MB-231 cells led to a significant decrease in both cell proliferation and migration (Figure 2A–2C). The gene discussed is MEIOB; the disease is breast carcinoma.