CR induced by IF inhibits the IGF-1/AKT and mTORC1 pathways in tumor cells, while adenosine 5 ́-monophosphate (AMP)-activated protein kinase (AMPK), which is dependent on the nicotinamide adenine dinucleotide coenzyme deacetylase-1 (Sirtuin-1, SIRT1) and SIRT3 pathways, is activated, thus hindering tumor cell growth. Here, SIRT3 is linked to neoplasm.