Treatment with dacetuzumab (SGN-40), a humanized IgG1 mAb targeting CD40, did not achieve improved complete remission when combined with rituximab and ifosfamide-carboplatin-etoposide (R-ICE) in relapsed, diffuse, large B-cell lymphoma (DLBCL) in a phase 2 study (NCT00529503). This evidence concerns the gene CD40 and diffuse large B-cell lymphoma.