Cutaneous CD30+ lymphoproliferative disorder (CD30+LPD) is the second most common form of CTCL, comprising a spectrum of diseases that range from lymphomatoid papulosis (LyP) to primary cutaneous anaplastic large cell lymphoma (PCALCL), which are characterized by a recurrent course and favorable prognosis3. Here, TNFRSF8 is linked to lymphoproliferative syndrome.