Transcriptome profiling before and after treatment with cobomarsen (an optimized anti-miR-155) identified miR-155 downstream targets involved in multiple survival pathways associated with CTCL oncogenesis, including JAK/STAT, MAPK/ERK, and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathways99. Here, AKT1 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.