We describe a case of a 30-year-old man with a locally aggressive form of papillary thyroid cancer with <i>EML4e13-ALKe20</i> fusion (<i>EML4</i>: echinoderm microtubule-associated protein-like 4; <i>ALK</i>: anaplastic lymphoma kinase). This evidence concerns the gene ALK and thyroid gland papillary carcinoma.