Liu et al. [11] reported that masses with spiculated margins were significantly more common in patients with luminal A breast cancer than in those with other subtypes; however, we studied that HR-positive tumors (all non-TNBC) including Her-2 +ve luminal B and Her-2 enrich cancers presented with predominantly spiculated margins and we also deduced that because of this same reason non-TNBC tumor more often causes architectural distortion/trabecular thickening as secondary sign of malignancy. This evidence concerns the gene ERBB2 and breast cancer.