At the same time, genomic studies have indicated that CSMD1 is implicated in several neurological related diseases like schizophrenia [24], cognitive impairment [9], multiple sclerosis [31], Alzheimer's Disease [32, 33], and familial Parkinson's disease [34], which provided strong support for the hypothesis that the CSMD1 KO mice will exhibit neuropsychological deficits [30]. This evidence concerns the gene CSMD1 and Alzheimer disease.