It was reported that Beclin1−/− mice die early in embryogenesis and aging; mice with Beclin1+/− are tumor-prone [134, 135], whereas mice with Atg5−/− and Atg7−/− are born normally, but die soon due to low nutritional level and suckling defects in neonates [136, 137]. This evidence concerns the gene BECN1 and neoplasm.