After controlling for age, sex, BMI, current smoking, HP, HLP, DM, CHD, AF, leukocyte, hemoglobin, TC, TG, LDL-C, HDL-C, FBG, and HbA1c (Model 2), compared with serum PON1 Q1 patients, serum PON1 Q3 (OR: 0.639; 95% CI: 0.362-0.876; p = 0.024) and Q4 (OR: 0.614; 95% CI: 0.327-0.834; p = 0.019) patients have a better functional prognosis. The gene discussed is PON1; the disease is atrial fibrillation.