A growing body of research data has evidenced the relationship between ROS and classical intracellular signaling pathways, such as those involving mitogen-activated protein kinase (MAPK), nuclear factor erythroid 2-related factor 2- (Nrf2-) ARE, phosphoinositide-3-kinase- (PI3K-) Akt, and Ca2+ in lung diseases [33, 34]. Here, NFE2L2 is linked to lung disorder.