Furthermore, other purinergic receptor (P2R) agonists and antagonists have been a drug candidate for the treatment of COPD and chronic cough; in particular, an antagonist at P2X2/3R antagonists and some of (P2R) agonists and antagonists might also be relevant for the treatment of other lung diseases [51, 52]. Here, P2RX2 is linked to chronic obstructive pulmonary disease.