Thus, mitochondrial dysfunction is the upstream core event that leads to the activation of NLRP3 inflammasome, which has been proven in several central nervous system diseases, such as Parkinson's disease [47, 48], postoperative cognitive dysfunction [49], cerebral ischemia-reperfusion injury [50, 51], and Alzheimer's disease [52], while it is not clear whether this activation mechanism also exists in ICH. Here, NLRP3 is linked to brain ischemia.