Similarly, another two inflammasome-related models of chronic kidney disease and sepsis-associated encephalopathy also demonstrated that Nrf2 deficiency decreased the activation of NLRP3 inflammasome and the release of its downstream productions IL-1β and IL-18, indicating that NLRP3 inflammasome activation depends on Nrf2 [32, 33]. Here, IL18 is linked to chronic kidney disease.