LEP and obesity due to melanocortin 4 receptor deficiency: Although some studies have found that the intervention of EGCG and TGR5 can improve the body's inflammatory state to a certain extent, thereby improving infertility, we should realize that obesity not only leads to male infertility from this aspect of the “obesity-inflammation-aromatase axis” but also causes male infertility from obesity-induced leptin resistance and oxidative stress damage, etc. [4, 41].