CCN2 and heart failure: PCR analysis showed significant decreases in heart failure markers (atriopeptin (ANP), brain natriuretic peptide (BNP), Acta-1, and β-MHC), proinflammatory factors (IL-6, TNF-α, and IL-1β), and fibrosis markers (connective tissue growth factor (CTGF), Collagen 1a1, and Collagen 3a1) in IKKε-KO mice compared with those of WT mice (Figures 4(a)–4(c)).