For instance, IKKε-deficient mice exhibit significantly reduced nociceptive behavior in comparison with that of wild-type mice [34]; mice that are deficient in IKKε were found to be protected from high-fat diet-induced obesity and showed reduced chronic liver inflammation, hepatic steatosis, and insulin resistance [35, 36]. This evidence concerns the gene IKBKE and obesity due to melanocortin 4 receptor deficiency.