In contrast to our results, Dai et al. [16] demonstrated that IKKε-deficient mice showed significantly enhanced cardiac hypertrophy, cardiac dysfunction, apoptosis, and fibrosis compared with those of WT mice, and these effects were associated with activation of the AKT and NF-κB signaling pathways in response to aortic banding. The gene discussed is IKBKE; the disease is cardiac hypertrophy.