At least twelve GWAS of asthma have been conducted and have yielded numerous associations, with the most significant (and in most cases replicated) associations occurring in or near the following genes: ORMDL3 [1, 2], PDE4D [21], HLADRB1 [2], HLA-DQ [2, 3], RAD50-IL13 [3], DENND1B [4], TLE4 [5], SMAD3 [2], IL1RL1 [22], IL18R1 [2], IL33 [2], IL2RB [2], RORA [2], and SLC22A5 [2]. The gene discussed is TLE4; the disease is asthma.