One was reported previously, rs147827524, encoded for pyrin and HIN domain family member 1 gene (PYHIN1) that has been accounted for HIN200 proteins which are primarily nuclear proteins involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis in addition to a surprisingly large proportion of asthma risk in people of African descent [39]. The gene discussed is PYHIN1; the disease is asthma.