The PI3K-Akt, MAPK, Ras, focal adhesion, HIF-1, and erythroblastic leukemia viral oncogene homolog (ErbB) signaling pathways coordinate diverse tumorigenic processes of cancer cells, involving cell proliferation and growth, survival and cell death, anoikis resistance, metastasis, EMT, self-renewal potential and stemness properties, and angiogenesis, of LC cells [101, 102, 107–125]. The gene discussed is EGFR; the disease is cancer.