The abnormal regulation of Akt1 (encoded by AKT1) and TNF-α (encoded by TNF) may enhance the growth, survival, proliferation, metastasis, epithelial-to-mesenchymal transition (EMT), and stemness capacity of LC cells, and they are potential targets that can alleviate chemotherapy and radiotherapy resistance [67–76]. The gene discussed is TNF; the disease is laryngotracheoesophageal cleft.