The genetic and epigenetic dysregulations in multiple cancer-associated genes and their key oncogenic signalings are implicated in the pathology of BC; these include the phosphoinositide 3-kinase- (PI3K-) Akt, tumor necrosis factor (TNF), forkhead box O (FoxO), erythroblastic leukemia viral oncogene homolog (ErbB), vascular endothelial growth factor (VEGF), hypoxia-inducible factor- (HIF-) 1, estrogen, p53, focal adhesion, and mitogen-activated protein kinase (MAPK) pathways [2–4]. The gene discussed is TNF; the disease is breast cancer.