In response to the effects of IFN-γ, the paracrine secreted tumor PGE2 promotes the translocation of p50 NF-κB into the nuclear of monocytes and macrophages, thereby contributing to the production of immunosuppressive nitric oxide, which induced the immune dysfunction of T lymphocyte by interfering TNF-α [101]. The gene discussed is NFKB1; the disease is neoplasm.