Additional analyses show that sulforaphane enhanced BDNF expression and increased levels of neuronal and synaptic molecules such as microtubule-associated protein 2 (MAP2), synaptophysin, and PSD-95, as well as elevated levels of synaptic TrkB signaling pathway components in primary cortical neurons and 3 × Tg-AD mice [50]. The gene discussed is BDNF; the disease is Alzheimer disease.