Further evidence that the 3D spheroid co-culture environment featured supportive interactions between its constituents was provided by the preservation of podoplanin and ICAM-1 expression on ADSC-derived lymphoid fibroblasts recovered from 3D DLBCL/ADSC/MDM spheroid co-cultures following cytokine removal (Supplementary Figure 6A). This evidence concerns the gene ICAM1 and diffuse large B-cell lymphoma.