described that IL-1b-dependent chemokine IL-8 (physiologically secreted by macrophages, endothelial, and epithelial cells) was associated with in vivo insulin secretion rates during an oral glucose tolerance test in healthy humans, even if no effect of recombinant human IL-8 on GIST in isolated mice islets was observed (38). Here, CXCL8 is linked to gastrointestinal stromal tumor.