To learn more about the signaling mechanisms that may be involved in the production of pro-inflammatory cytokines in response to glaucomatous injury, we measured the changes in the mRNA transcript of transcription factors, signal transducer and activator of transcription (e.g., STAT1, STAT2, and STAT3) in the retina of normal and ocular hypertensive animals. The gene discussed is STAT1; the disease is ocular hypertension.