Finally, it converted SSBs into DSBs and impelled cell death in HR-deficiency tumor, for example BRCA1/2 mutations, RAD51 deficiency (Figure 2) (Konecny and Kristeleit, 2016; Brown et al., 2017; Lord and Ashworth, 2017; Oplustil O’Connor et al., 2016). Here, RAD51 is linked to neoplasm.