It has been reported that high MGMT expression in tumor cell is associated with the resistance to 1,3- bis- (2-chloroethyl) -1- nitrosourea (BCNU) and temozolomide (TMZ) (Happold et al., 2018; Hsu et al., 2018), which target the O6-position of guanine, resulting in cytotoxic and mutagenic DNA adducts (Rabik et al., 2006). Here, MGMT is linked to neoplasm.