CD274 and urothelial carcinoma: Metastatic urothelial carcinoma (mUC) shown relatively low response rates to PD-1/PD-L1 blockade (15–24%), whereas the presence of DDR gene mutations is a potential marker of clinical benefit from anti-PD-1/PD-L1 immune checkpoint inhibitors in mUC (Teo et al., 2018).