CCNB1 and colonic neoplasm: Cell cycle is a continuous system of biological processes, and several studies have elucidated that the lower level of CDK1 and CCNB1 in colon tumor cells slowed down the G2/M phase of the cell cycle, which owned to the retardation of cell cycle in the S phase (Ryu et al., 2009; Wang et al., 2017).