For example, a Dutch study did define a genetic passport that included several loci (TPMT, NUDT15, HLA-DQA1*02:01-HLA-DRB1*07:01, and HLA-DQA1*05) associated with toxic effects from thiopurines (i.e., myelosuppression and pancreatitis) and anti-TNFα mABs (i.e., immunogenicity) (Bangma et al., 2020). Here, NUDT15 is linked to pancreatitis.