MKI67 and neoplasm: To further explore the effects of VO(hntdtsc)NPIP on cell proliferation in HeLa xenografts, immunohistochemical staining was conducted and the results was shown in Figure 8, revealing that the VO(hntdtsc)NPIP treatment significantly reduced the cell positive rate with Ki-67 staining (F = 140.22, p < 0.001) and enhanced the cell positive rate with p16 staining (F = 79.55, p < 0.01), suggesting that VO(hntdtsc)NPIP obviously inhibited the proliferation index of HeLa cell xenografts and reduced the malignant degree of the transplanted tumor.