Therefore, corticosterone is utilized as a marker for assessing stress in studies of humans and animals alike (Costantini et al., 2011; Kalliokoski et al., 2019); additionally, elevated levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 may serve as biological markers of anxiety disorders (Sevastre-Berghian et al., 2018). This evidence concerns the gene TNF and anxiety disorder.