CDK1 and breast cancer: Our results showed that the activity of Cdc25C was inhibited significantly by TAIII in a concentration- and time-dependent manner (Figures 1B,C), accompanied with the inhibition of Cdc2, then the formation of MPF was inhibited and finally induced G2/M phase arrest in breast cancer cells, suggesting TAIII affects coherent pathways that regulate Cdc25C kinase activity.