Gergely J et al. found that TAIII significantly inhibits the proliferation, migration and invasion of breast cancer cells and induces the senescence of breast cancer cells by inhibiting he activity of polycomb repressive complex 1 (the core protein of polycomb complex) histone post-translational modification and reducing the expression of its core member BMI1 in breast cancer cells (Gergely et al., 2018). The gene discussed is BMI1; the disease is breast carcinoma.