The results showed that the nodes of TP53, AKT1, VEGFA, EGFR, MAPK3, CCND1, HRAS, CASP3, SRC, ALB, JUN, STAT3, HSP90AA1, IL6, MAPK1, ESR1, ERBB2, TNF, MAPK8, MTOR, FGF2, and MMP9 are larger and brighter, indicating that they play a major role in the treatment of lung cancer. This evidence concerns the gene ESR1 and lung cancer.