These findings on sinensetin were consistent with increment of rhodamine-123 accumulation in AML-2/D100 (Choi et al., 2002), reduced talinolol transport by P-gp from basolateral to apical (BL/AP) side in Caco-2 colon carcinoma cell monolayer model (Mertens-Talcott et al., 2007) and increased uptake of [3H] vincristine into adriamycin-resistant human myelogenous leukemia (K562/ADM) cells (Ohtani et al., 2007). Here, PGP is linked to acute myeloid leukemia.