On the other hand, HNF4a may affect the expression levels of other important circadian clock genes, such as elevated BMAL1 levels, which indirectly affect the regulatory genes and cell signaling pathways involved in DNA damage repair, inflammatory response, cellular metabolism, etc., which can enable cancer cells to avoid deterioration and invasion easily; however, the specific molecular mechanism needs to be researched further. This evidence concerns the gene HNF4A and cancer.