Thus, phosphorylated tau at Ser396/Ser404 sites, epitope known as PHF-1, is a modified form that can induce synaptic failure19, the formation of intracellular deposits20, and cognitive impairment in different pathologies, including tauopathies and Alzheimer’s disease (AD)21. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.