ANXA1 and inflammatory bowel disease: Similarly, it has been reported that Annexin 1 was up-regulated during response to inflammatory bowel disease in humans47, which resemble SBMIE in fish, as reported in previous literature15,48 The positive correlation in immunological responses between the FM, ACJ, AWA and ICU diets suggested that the ability of ACJ, AWA and ICU to counteract SBMIE was linked to immune responses.