Bile acids have been identified to accelerate the development of Barret-like metaplasia, and given the prominent expansion of Dclk1-positive tuft cells in the cardia of murine and human Barrett ́s metaplasia3 in conjunction with the data presented in this study it appears feasible to postulate an important modulatory role of tuft cells in BE formation. Here, DCLK1 is linked to Barrett esophagus.