pL2-IL1b mice robustly develop by 6 months of age chronic inflammation and epithelial hyperplasia at the squamo-columnar junction (SCJ), which progresses to severe columnar metaplasia by 12–15 months of age and then to high-grade dysplasia (HGD) or EAC formation at later timepoints, thus mimicking human BE pathology3. This evidence concerns the gene IL1B and Barrett esophagus.