EGFR and glioblastoma: It is found that amplification of the epidermal growth factor receptor (EGFR) gene is the most frequent genetic change associated with GBM, and GBM exhibits that amplified EGFR frequently overexpresses the receptor variant III (EGFRvIII)3, which implies the critical influence of EGFRvIII toward increased proliferation of glioma cells4.