Integrating data from several lines of evidence described above, as well as the cross-ancestry fine-mapping and genetic pathways, provided support for specific genes potentially influencing POAG risk particularly RERE, VCAM1, ZNF638, CLIC5, SLC2A12, YAP1, MXRA5, and SMAD6 (Table 1 and Supplementary Data 14). The gene discussed is ZNF638; the disease is open-angle glaucoma.