Given that three POAG risk loci that we identified (loci containing MAPT, CADM2, and APP) have also been implicated in Alzheimer’s disease (AD) and dementia26–28, we asked whether the same causal variants may underlie these loci and whether there is evidence for genetic sharing in any of the other genome-wide significant POAG loci. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.