CD4 and neoplasm: Treatment with DT2216 had no global effect on the overall levels of Treg, CD4+ Tconv, CD8+ T, NK cells, and B cells from various tissues within non-tumor bearing mice (Supplementary Fig. 9a–e), nor did we see significant difference in CD8 T cell memory and effector sub-populations from these tissues (Supplementary Fig. 9f–i), defined by CD45RA and CCR7 (Supplementary Fig. 2a, b).