LGALS3 and neoplasm: Other described glycosylation-related changes in PDAC are upregulation of sialyl LewisX, truncated O-glycans, galectin-1 and galectin-3, specific proteoglycans and increased branched and fucosylated N-glycans, which are all associated with distinct aspects of tumour progression such as tumour cell proliferation, invasion, metastasis, inflammation and angiogenesis12.