Increased sialylation was facilitated by enhanced expression of different enzymes involved in the synthesis of the sugar donor (Sialic acid-CMP), and also some sialyltransferases as ST3GAL1, ST6GAL1, ST6GAL2 and ST6GALNAC1. Previous studies showed that ST3Gal3 and ST3Gal4 were overexpressed in PDAC which was linked to increased migration metastatic ability of cancer cells32,33. Here, ST6GAL1 is linked to cancer.