The results showed that Gfap, Rhog, Gnai2, Ppp1r1b, and Uqcrh were specifically dysregulated in the prefrontal cortex of the depression-susceptible group, while Tubb6, Urod, Cul1, Spred1, and Gpcpd1 were specifically dysregulated in the anxiety-susceptible group. Here, SPRED1 is linked to major depressive disorder.