Unexpectedly, although the treatment of El alone failed to induce the differentiation of CML cells, the combination of MSCs and El did trigger synergistic megakaryocytic differentiation in K562 cells, substantiated by higher expression levels of CD41, CD42, and CD61, as well as increased cell size than MSCs treatment alone (Fig. 4A, B). This evidence concerns the gene ITGB3 and chronic myelogenous leukemia, BCR-ABL1 positive.