The results suggested that mRNA levels of typical megakaryocytic differentiation makers and transcription factors, including CD41, CD42b, CD61, NFE2, GATA1, and FLI1, were significantly upregulated in CML cell lines (K562, LAMA-84 cells) (Figs. 2A and S3A). This evidence concerns the gene GATA1 and chronic myelogenous leukemia, BCR-ABL1 positive.