The results suggested that mRNA levels of typical megakaryocytic differentiation makers and transcription factors, including CD41, CD42b, CD61, NFE2, GATA1, and FLI1, were significantly upregulated in CML cell lines (K562, LAMA-84 cells) (Figs. 2A and S3A). Here, FLI1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.