Meanwhile, K562 cells treated by MSCs resulted in the loss of expression of erythroid genes including HBA1, HBB, HBE1, and KLF1 (Fig. S3D), suggesting that MSCs boosted megakaryocytic-biased differentiation of CML cells. The gene discussed is KLF1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.