The results suggested that mRNA levels of typical megakaryocytic differentiation makers and transcription factors, including CD41, CD42b, CD61, NFE2, GATA1, and FLI1, were significantly upregulated in CML cell lines (K562, LAMA-84 cells) (Figs. 2A and S3A). The gene discussed is ITGB3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.