Cytokine release syndrome (CRS) is a toxic side effect of CAR-T therapy; CRS is characterized by fever and hypotension associated with elevated serum cytokines (such as IL-6).48 The results showed the serum cytokine IL-6 did not increase significantly with CD105 CAR-T treatment and no symptoms of fever was observed, indicating that CD105 CAR-T treatment showed no obvious toxicity in mice. Here, IL6 is linked to congenital rubella syndrome.