For example, in gastric cancer, a variety of circRNAs, such as circHIPK3, ciRS-7, and circPVT1, are upregulated to promote the occurrence and development of cancer, while circ-KIAA1244, circRNA_100269, and circ-YAP1, which play various roles in inhibiting cancer, are downregulated in gastric cancer. The gene discussed is ARFGEF3; the disease is gastric cancer.