In CRC tissues and SW480 cells, the expression of circRNA-ACAP2 and Tiam1 is increased, while the expression of miR-21-5p is decreased, indicating that circRNA-ACAP2 and Tiam1 may promote the growth of tumor cells, while miR-21-5p acts as an inhibitor of tumor growth86. This evidence concerns the gene ACAP2 and neoplasm.