APP and Alzheimer disease: Among other ROH regions in or near to known AD loci (Supplementary Tables 6 and 10), we highlighted a 237 Kb ROH upstream the APP gene (chr21: 26,903,551–27,141,292), by its known role in AD7,8,36; detected in 38 AD cases vs 26 controls (26 vs 12 inbred individuals, respectively).