We reported that Nrf2 activator sulforaphane (SFN) showed antidepressant-like effects in the lipopolysaccharide (LPS)-induced and chronic social defeat stress (CSDS) models of depression by stimulating the expression of brain-derived neurotrophic factor (BDNF)8,10,11, and that Nrf2 activators such as TBE-31 and MCE-1 showed antidepressant-like effects in LPS-induced model of depression12. Here, NFE2L2 is linked to major depressive disorder.